Contemporary Clinical Dentistry
  Home | About us | Editorial board | Search
Ahead of print | Current Issue | Archives | Advertise
Instructions | Online submission| Contact us | Subscribe |


Login  | Users Online: 243  Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size 

Year : 2022  |  Volume : 13  |  Issue : 2  |  Page : 118-124

Assessing the antimicrobial properties of copper-iodide doped adhesives in an In vitro caries model: A pilot study

1 Department of Oral Rehabilitation, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA
2 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA
3 Dentist, Private Practice, Spokane, WA, USA
4 Department of Medicine, Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA
5 Department of Restorative Dentistry, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY, USA
6 Department of Oral Rehabilitation and Restorative Dentistry, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA
7 Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA

Correspondence Address:
Dr. Anthony S Mennito
Department of Oral Rehabilitation, Medical University of South Carolina, 173 Ashley Ave. BSB 550E, MSC 507, Charleston, SC 29425
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccd.ccd_424_20

Rights and Permissions

Context: Recurrent caries are the leading cause of composite resin failure. Aims: The purpose of this pilot study was to test the efficacy of a novel copper iodide (CuI) containing dental adhesive in an in vitro caries model. Subjects and Methods: Streptococcus mutans and Lactobacillus acidophilus were grown individually on the complex medium for 48 h at 37°C. The pH of the mixed medium was 7.0 initially and tested every 24 h. 40 extracted teeth were prepared with standardized cavity preparations and coated with control or experimental CuI adhesives and imaged using a micro-computed tomography (microCT). Four study groups were evaluated: (1) control (2) 0.5 μg/ml CuI (3) 1.0 μg/ml CuI, 4) 5.0 μg/ml CuI. After incubation, the teeth were re-imaged using the microCT. Utilizing AnalyzePro software the three-dimensional data sets were overlaid and demineralization was measured and statistics were run. Statistics: Stratified ANOVA models were run to determine if there were differences between the control and experimental adhesive groups. Similarly, pH and bacterial concentrations were evaluated to ensure the viability of polymicrobial specimen. Results and Conclusions: Significant differences were found between the control group and the 1.0 and 5.0 CuI adhesive groups. No differences in pH were noted between the groups. Overlaid changes in demineralization were recorded as volume loss. CuI adhesives with 5 mg/ml or higher have the potential to limit tooth demineralization after bacterial penetration of a dental restoration in an in vitro caries model. Further testing is needed.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded190    
    Comments [Add]    

Recommend this journal