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Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 117-122

Persica chewing gum effects on saliva fluoride concentration and flow rate: A triple-blind randomized clinical trial

1 Department of Pediatric Dentistry, Dental Research Centre, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pharmaceutics, School of Pharmacy, Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Shiva Mortazavi
Department of Pediatric Dentistry, Dental Research Centre, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccd.ccd_509_18

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Context: Dental caries is a prevalent disease worldwide. Salvadora persica or Miswak could be a source of fluoride and has caries preventive effects. Aims: The aim of this study was to compare saliva fluoride concentration and flow rate after using Persica and sodium fluoride chewing gums. Settings and Design: In a triple-blind crossover randomized trial, 44 healthy volunteers (21–25 year old) were recruited according to the inclusion criteria and were randomly allocated into two groups (22 each). Participants and Methods: This study was performed within two sets of trial with a 10-day washout period. Participants (subjects) were followed a running period and matched for trial confounders. Saliva samples were collected under controlled conditions at similar time (11 am) within baseline, 5, 10, 20, and 45 min intervals preceded by 5-min chewing of Persica or sodium fluoride chewing gum. Saliva samples were analyzed for fluoride ion using hexamethyldisiloxane diffusion method. Statistical Analysis Used: Saliva flow rate (ml/min) and mean fluoride concentration (ppm) during different time periods in two types of gum were compared using ANOVA-repeated measures (P < 0.05). Results: The difference in total means of stimulated saliva flow rates between two Persica and sodium fluoride gum intervention groups was statistically significant (P = 0.048); however, difference of fluoride concentrations was not statistically significant (P = 0.244). Conclusions: Chewing Persica containing gum released fluoride ions in saliva and increased saliva flow rate comparable with sodium fluoride chewing gum use as a gold standard.

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